Steven M. Muskal Professional Headshot

Steven M. Muskal, Ph.D.

AI Pioneer | Drug Discovery Expert | Creative Innovator | Serial Inventor

CEO of Eidogen-Sertanty with over 40 years of experience at the intersection of AI, chemistry, biology, and drug discovery. Passionate about leveraging technology to solve complex problems and improve human health.

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Professional Excellence

Current Leadership

Chief Executive Officer - Eidogen-Sertanty
Leading the development of innovative AI-driven solutions for drug discovery and computational chemistry, bridging the gap between molecular science and practical therapeutic applications.

Areas of Expertise

AI & Machine Learning

Four decades of experience applying AI to solve complex scientific challenges

Drug Discovery

Pioneering computational approaches to accelerate therapeutic development

Computational Chemistry

Expert in molecular modeling and structure-based drug design

Data Science

Advanced analytics and big data solutions for life sciences

Career Highlights

Distinguished Career Path

Education

Deep Dive Audio

Listen to audio versions of my articles and insights. Each Substack article has an accompanying audio deep dive.

🎧 Site Overview Audio

Get a complete audio summary of my work, research, and creative projects.

Renaissance Circle Network Renaissance Circle Podcast Renaissance Circle Network

Steven M. Muskal, Ph.D. - AI Pioneer, Drug Discovery Expert, Innovator, and Musician
Explores science, business, and the art of feeling good.
Where innovators, scientists, and entrepreneurs discuss the future of health and performance

🎙️ Latest: Food Is Medicine. But First It Has to Become Data.

A practical look at improving nutrition quality first, so health outcomes are driven by real food, not marketing labels.

The related Food Health support page now includes two side-by-side app demos showing how meals become structured, reviewable data.

Food Is Medicine. But First It Has to Become Data.
Read on Substack → See Food Health demos →

Innovation & Projects

AI-Driven Drug Discovery

Developing machine learning models for predicting drug-target interactions and optimizing lead compounds to accelerate the path from discovery to clinical trials.

View Publications →
40+ Years Neural Network Journey

40+ years of neural network and AI research journey

Food Health AI

Food Health AI turns meals into structured, reviewable nutrition data with photo capture, note capture, AI analysis, and fast edit flows. It is the practical product expression of the March 8, 2026 Renaissance Circle piece, Food Is Medicine. But First It Has to Become Data.

Current Demo

The existing walkthrough shows the current meal-to-data capture flow on the live app.

New V4 Demo

The newer V4 video adds another quick look at the updated Food Health AI experience.

Live Food Showcase

This preview loads the live Food Showcase page, so updates on `foodhealthscan.com` show up here automatically.

AI-Steve: Personal Research & Coaching Assistant

My daily companion for research recall, journaling, and family knowledge capture. AI-Steve pulls in emails and attachments, calendar events, to-do items, iMessages, Mac Photos plus curated imports, chat sessions, Q&A, and Socratic pairs extracted from mail, embedding them into PostgreSQL so Claude can respond with grounded context. Search Content, sentiment, and health intelligence fuel daily reflections (including 1, 3, 5, 7, and 10-year lookbacks) plus end-of-week recaps that project the week ahead. Built entirely through natural-language coding (speaking into Wispr Flow driving agentic CLIs like Droid, Claude Code, Codex, Gemini CLI) and able to handle small coding or automation projects on demand, similar to how I built Toast apps and AI-Dad.

Features at a glance

PostgreSQL + embeddings Claude reasoning Multi-source ingest Chat history memory
AI-Steve interface

Chat UI grounded in embeddings and transcripts with instant access to images and stats.

Multi-year reflections preview

Multi-year reflections surfaced daily (1, 3, 5, 7, 10 years ago).

AI-Steve data sources distribution

Live mix of emails, Q&A, photos, attachments, calendar, to-dos, iMessages, and curated imports.

User-modifiable RAG weight control.

RAG weights control panel
AI-Steve Architecture →

Image Explorer: Visual Memory Engine

A CLIP (Contrastive Language–Image Pre-training) + pgvector-powered explorer for my photo archives. Nightly clustering keeps similar sets together so I can browse clusters, select many images at once, and annotate entire groups without touching each file. I can also annotate straight from similarity search, including sub-images and video frames, accelerating how visuals become structured context for AI-Steve’s RAG. Built by speaking English into Wispr Flow to orchestrate Droid, Claude Code, Codex, Gemini CLI, similar to Toast apps, AI-Dad, and AI-Steve.

What it does
  • 🔍 Similarity search with thresholds
  • 🗂️ Nightly clustering; annotate whole sets
  • 📝 Inline annotations saved to DB + JSON
  • 🖼️ Finder deep links for fast triage
Image Explorer similarity and annotation UI

Bulk similarity hits with instant “Annotate Selected” to speed group labeling.

Image Explorer annotation modal

Annotation modal on similarity results to label entire groups in one pass.

Face clustering example across decades

Face extraction and clustering from Mac Photos and video frames, enabling rapid tagging and propagation.

Face clustering sunglasses and hats

Robust matching across sunglasses, hats, and lighting to keep face IDs consistent.

Image Explorer Architecture →

CT Viewer Story: DICOM → Interactive 3D

A real-world build story: I received a USB drive full of DICOM CT slices after a root canal, and instead of using a PC-only viewer, I described the problem to an AI coding assistant and walked away. Minutes later, I had a working browser-based viewer with 3D rotation, cross-sectional MPR views, and contrast controls.

CT Viewer with 3D jaw model and cross-sectional views

Interactive 3D jaw reconstruction with axial, sagittal, and coronal slice navigation.

CT Viewer Story → GitHub Source →

Apple Health Integration: Quantified Sleep + Recovery

Daily Apple Health exports power a dedicated analytics pipeline inside AI-Steve. Correlation engines, lag analysis, and a sleep-concentration model surface the behaviors most tied to deep sleep and REM recovery. The resulting plots are stored as visual artifacts so they’re searchable and reviewable alongside photos and other memory assets.

Full Apple Health correlation heatmap

Full correlation heatmap across Apple Health metrics.

Sleep-focused correlation heatmap

Sleep-focused correlation matrix highlighting top 30 predictors.

Feature importance for sleep concentration prediction

Top 20 features driving sleep concentration prediction.

Top correlates with deep sleep

Top correlates with deep sleep for recovery drivers.

Top correlates with REM sleep

Top correlates with REM sleep for cognitive recovery signals.

Apple Health Architecture →
Share Health app icon

Share Health: App Store Export Companion

Share Health is the companion iOS app that makes consistent, time‑aligned Apple Health exports simple. It packages daily signals for longitudinal analysis with clean CSV outputs, optional face imagery, and on‑device Face → Health modeling.

• Face → Health (v5.3): train personalized models from facial analysis (Linear Regression or Random Forest).
• Export 100+ Apple Health metrics to CSV, with optional daily face imagery.
• Share Steps workflow for missed-device days and group challenges.
• Privacy-first: on-device storage, no accounts, you control exports and sharing.
Face to Health model snapshot Resting heart rate analysis Sleep REM analysis Single-day health export Share steps workflow Import steps

Face → Health modeling + export workflows (3×2 layout).

App Store → More Details → GitHub GitHub Source →

Face → Health: Vision as a Longitudinal Signal

Face → Health treats the face as a sensor, not a narrative. Daily images support both retrospective (last night) and predictive (tonight) sleep modeling with strict temporal alignment. Health-specific vision analysis, dual embeddings, and a materialized ML view make this a defensible, longitudinal wellness signal.

Face to Health overview

Temporal self‑awareness: face today → sleep tonight (recorded tomorrow).

Face → Health →

AI-Steve Code Directives: Domain-Specific Auto-Coding

Added into my AI-Steve infrastructure is the ability to auto-code projects in a domain-specific way using simple natural language project descriptions on top of Droid, Claude, and/or Codex. What brought it to the next level is using AI-Steve’s RAG system to wrap a project direction in my voice - imagine enabling all your coders to code given their own past projects and insights. It is akin to saying: build this new OS in the voice of Linus Torvalds.

AI-Steve code directives workflow

Domain-specific guidance + RAG voice overlay drive code generation, review loops, and polished reporting.

Key elements: domain prompts, RAG context, peer review, self-healing retries, and packaged reports.

Designed to make project requests feel like they were built by the same voice that created the original system.

AI-Steve Code Directives →

AI-Dad: Preserving Legacy Through Conversational AI

An innovative application of RAG (Retrieval-Augmented Generation) technology to create an interactive AI assistant embodying 60+ years of intellectual property legal expertise and family wisdom. Built using natural language programming and Claude Code, this deeply personal project preserves my father's extensive knowledge in IP law alongside decades of family history and personal interactions, making his guidance on both legal and life matters accessible for future generations.

AI-Dad Legal Guidance

Legal Expertise

AI-Dad Family Wisdom

Family Wisdom

AI-Dad: Always here for you - Combining decades of legal expertise with heartfelt family wisdom

Coming Soon: AI-IP-Lawyer →

Intellectual Property Attorney for over 60 years

🔬 Drug to Table Project (Finding Drugs Hidden in Your Food)

Remarkable 3D molecular alignment between Pravastatin (cholesterol drug) and Ganoderic acid from Reishi mushrooms. This innovative "reverse screening" approach explores how natural compounds in food mirror pharmaceutical drugs. Visit DrugToTable.com →

🥂 Toast Our Friend - A New Way to Celebrate

While the world focuses on self-promotion, we're building a place to honor the people around you. Share stories, create tributes, and celebrate the lives that touch yours.

Each app focuses on different communities and ways to celebrate friendships through meaningful connections.

Music & Creative Sessions

Each week, different combinations of musicians are invited for Mix-n-Match sessions with no specific setlist or plan. Pure musical improvisation and collaboration.

YouTube Channel Visit My YouTube Channel

Example Mix Sessions

Renaissance Circle - Dr. Steven Muskal's Pulse Substack

Example Presentations

Recent

My 38-Year Journey with Neural Networks: Can They Further Unlock Pichia's Potential?

Conference presentation on the application of neural networks to unlock the potential of Pichia pastoris in biotechnology and protein expression systems.

Blast From The Past

Historic Presentation from 2010 (15+ years ago. Always on the "bleeding edge...")

A look back at research and insights from 2010.

View Publications & Presentations →